Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits.

Min WangTimothy P HancockAmanda J ChamberlainChristy J Vander JagtJennie E PryceBenjamin G CocksMike E GoddardBenjamin J Hayes

Published in: BMC genomics (2018)

Our results suggest that genomic synteny can be used to functionally annotate conserved transcriptional components, and provides a tool to reduce the search space for causative regulatory variants in the bovine genome.

Keyphrases

transcription factor
copy number
genome wide
dna binding
dna methylation
binding protein
heat shock