A comparison of domain-specific evaluations of life in predicting overall life evaluations and biological inflammation.

Which domain of life evaluation is more important? Using a large-scale public sample of 1888 adults from the United States (880 males, 1008 females; M age  = 53.28), we addressed this question by comparing the predictive strength of six domains of life evaluations on overall life evaluation as well as biomarkers of inflammation. Specifically, we examined individuals' self-rated evaluations of the domains of social belonging, romantic relationships, work, subjective social status, self-esteem and finances, and we examined biological inflammation using an index of five biomarkers of inflammation: interleukin-6, fibrinogen, C-reactive protein, E-selectin and intercellular adhesion molecule 1. Adjusting for demographic variability, romantic evaluation, work evaluation, self-esteem and financial evaluation were equally and uniquely predictive of overall life evaluation. Social belonging remained predictive but was relatively weaker in magnitude, while subjective social status was no longer a significant predictor. Conversely, only financial evaluation was significantly linked to reduced biomarkers of inflammation. The findings suggest that depending on domain-specificity and whether well-being is assessed via subjective or objective indicators, links between life evaluations and well-being may show substantial nuance. In particular, financial evaluation appears to have unique links to biomarkers of inflammation even after accounting for other domains of life evaluations.