EYA2 Tyrosine Phosphatase Inhibition Reduces MYC and Prevents Medulloblastoma Progression.
Arthur R WolinMelanie Y VincentTaylor HotzStephen C PurdySheera R RosenbaumConnor J HughesJessica Y HsuMichael U J OliphantBrock ArmstrongVeronica WessellsMarileila Varella-GarciaMatthew D GalbraithAngela PierceDong WangSujatha VenkataramanEtienne DanisBethany VeoNatalie SerkovaJoaquín Maximiliano EspinosaDaniel L GustafsonRajeev VibhakarHeide L FordPublished in: Neuro-oncology (2023)
Our data demonstrate that EYA2 is a critical regulator of MYC in Group 3 MB and suggest a novel therapeutic avenue to target this highly lethal disease.