Early growth response 1 (EGR1) is downregulated in peripheral blood from patients with major psychiatric disorders.
Giovana BristotJacson Gabriel FeitenBianca PfaffensellerGabriel Henrique HizoGabriela Maria Pereira PossebonFernanda Endler ValiatiJairo Vinícius PintoMarco Antonio CaldieraroMarcelo Pio de Almeida FleckClarissa Severino GamaMárcia Kauer-Sant'AnnaPublished in: Trends in psychiatry and psychotherapy (2024)
EGR1 is downregulated in psychiatric patients, regardless of the diagnosis and may be a potential common target in major psychiatric disorders. EGR1, as a transcription factor, modulates many other genes and participates in crucial neuronal and synaptic processes, such as plasticity, neurotransmitters metabolism, vesicular transport and signaling pathways. The study of EGR1 and its upstream regulators in psychiatry might lead to potential new therapeutic targets.