Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging.
Julien DumurgierSéverine SabiaHenrik ZetterbergCharlotte E TeunissenBernard J HanseeuwAdelina OrellanaSusanna SchraenAudrey GabelleMerce BoadaThibaud LebouvierEline A J WillemseEmmanuel CognatAgustin RuizClaire HourregueMatthieu LilamandElodie Bouaziz-AmarJean-Louis LaplancheSylvain LehmannFlorence PasquierPhilip ScheltensKaj BlennowArchana Singh-ManouxClaire Paquetnull nullPublished in: Neurology (2022)
The proposed novel, pragmatic method to determine CSF biomarkers cut-offs for AD does not require assessment of other biomarkers or assumptions concerning the clinical diagnosis of patients. Use of this standardized algorithm is likely to reduce heterogeneity in AD classification.