Increased Risk of Atopic Diseases in the Siblings of Patients with Autism Spectrum Disorder: A Nationwide Population-Based Cohort Study.
Ying-Xiu DaiYing-Hsuan TaiYun-Ting ChangTzeng-Ji ChenMu-Hong ChenPublished in: Journal of autism and developmental disorders (2020)
Several studies have shown a strong association between atopic diseases and autism spectrum disorder (ASD). However, the risk of atopic diseases in individuals having ASD-affected siblings has never been investigated. This nationwide population-based cohort study included 2762 individuals with ASD-affected siblings and 11,048 controls. Diagnoses of atopic diseases, including asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis, were ascertained from 1996 or the birth data to the end of 2011. Individuals with ASD-affected siblings had a higher risk for asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and multiple atopic diseases compared with controls. In conclusion, individuals with ASD-affected siblings were more likely than were the controls to develop atopic diseases, suggesting shared familial mechanisms underlying the two conditions.
Keyphrases
- atopic dermatitis
- autism spectrum disorder
- allergic rhinitis
- intellectual disability
- attention deficit hyperactivity disorder
- end stage renal disease
- newly diagnosed
- ejection fraction
- machine learning
- peritoneal dialysis
- big data
- pregnant women
- mass spectrometry
- preterm birth
- artificial intelligence
- deep learning
- high speed