Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties.
Amber F MacDonaldAhmed BettaiebDallas R DonohoeDina S AlaniAnna HanYi ZhaoJay WhelanPublished in: BMC complementary and alternative medicine (2018)
Therefore, this is the first evidence that natural products simultaneously and antithetically regulate upstream kinases, known to be involved in cancer, via the activation of AMPK.