Low-dose melatonin for sleep disturbances in early-stage cirrhosis: A randomized, placebo-controlled, cross-over trial.

Arjuna P De SilvaMadunil A NiriellaDileepa Senajith EdiriweeraJerome P De AlwisIsurujith K LiyanageUshanthani EttickanKasun V LiyanapathiranaChandimani UndugodageH Asita de SilvaH Janaka de Silva

Published in: JGH open : an open access journal of gastroenterology and hepatology (2020)

Melatonin seems safe and effective for use in patients with SDs in early-stage cirrhosis in the short term. However, larger and longer-term studies to assess efficacy and safety are required before its clinical use can be recommended.

Keyphrases

early stage
low dose
placebo controlled
phase iii
study protocol
phase ii
double blind
sentinel lymph node
clinical trial
high dose
preterm infants
physical activity
sleep quality
open label
case control
depressive symptoms
radiation therapy
lymph node
locally advanced