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Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications.

Lindsay B BakerJeffrey B ModelKelly A BarnesMelissa L AndersonStephen P LeeKhalil A LeeShyretha D BrownAdam J ReimelTimothy J RobertsRyan P NuccioJustina L BonsignoreCorey T UngaroJames M CarterWeihua LiMelissa S SeibJonathan T ReederAlexander J AranyosiJohn A RogersRoozbeh Ghaffari
Published in: Science advances (2020)
Advanced capabilities in noninvasive, in situ monitoring of sweating rate and sweat electrolyte losses could enable real-time personalized fluid-electrolyte intake recommendations. Established sweat analysis techniques using absorbent patches require post-collection harvesting and benchtop analysis of sweat and are thus impractical for ambulatory use. Here, we introduce a skin-interfaced wearable microfluidic device and smartphone image processing platform that enable analysis of regional sweating rate and sweat chloride concentration ([Cl-]). Systematic studies (n = 312 athletes) establish significant correlations for regional sweating rate and sweat [Cl-] in a controlled environment and during competitive sports under varying environmental conditions. The regional sweating rate and sweat [Cl-] results serve as inputs to algorithms implemented on a smartphone software application that predicts whole-body sweating rate and sweat [Cl-]. This low-cost wearable sensing approach could improve the accessibility of physiological insights available to sports scientists, practitioners, and athletes to inform hydration strategies in real-world ambulatory settings.
Keyphrases
  • high throughput
  • low cost
  • blood pressure
  • machine learning
  • soft tissue
  • heart rate
  • primary care
  • risk assessment
  • single cell
  • big data
  • physical activity
  • body mass index
  • clinical practice
  • quantum dots