Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya.

Stella Wanjiku GikunjuEric L AgolaRaphael Omusebe OndondoJohnson KinyuaFrancis KimaniAngelle Desiree LaBeaudIndu MalhotraCharles KingKelvin Thiong'oFrancis Mutuku

Published in: Malaria journal (2020)

The data suggest a high prevalence of P. falciparum genetic variations conferring resistance to SP among pregnant women, which may explain reduced efficacy of IPTp treatment in Kenya. There is need for extensive SP resistance profiling in Kenya to inform IPTp drug choices for successful malaria prevention during pregnancy.

Keyphrases

plasmodium falciparum
primary care
risk factors
healthcare
electronic health record
adverse drug
genome wide
big data
gene expression
dna methylation
artificial intelligence