COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men.
Alexis R DemonbreunAmelia SancilioMatt E VelezDaniel T RyanLorenzo PesceRana SaberLauren A VaughtNina L ReiserRyan R HsiehRichard T D'AquilaBrian MustanskiThomas W McDadeElizabeth M McNallyPublished in: The Journal of infectious diseases (2021)
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
Keyphrases
- coronavirus disease
- polycystic ovary syndrome
- sars cov
- pregnancy outcomes
- middle aged
- binding protein
- cervical cancer screening
- respiratory syndrome coronavirus
- healthcare
- breast cancer risk
- insulin resistance
- type diabetes
- mental health
- adipose tissue
- mass spectrometry
- quality improvement
- dna binding
- current status