Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers.
Katherine E HutchinsonJessica W ChenHeidi M SavageThomas J StoutFrauke SchimmollerJavier CortésSusan DentNadia HarbeckWilliam JacotIan KropSally E TrabuccoSmruthy SivakumarEthan S SokolTimothy R WilsonPublished in: Genome medicine (2023)
Our study establishes clonal multiple PIK3CAmut as an important molecular determinant of response to p110α inhibition and provides rationale for further clinical investigation of p110α inhibitors alone or with rationally-selected therapies in breast cancer and potentially other solid tumor types.