Inflammation-dependent and independent airway remodelling in asthma.
John G ElliotPeter B NobleThais MauadTony R BaiMichael John AbramsonKaren O McKayFrancis H Y GreenAlan L JamesPublished in: Respirology (Carlton, Vic.) (2018)
These findings suggest that inner and outer wall thickening coexists with inflammation, whereas thickening of the ASM layer and basement membrane may be present even in the absence of inflammation. Remodelling of the ASM layer and basement membrane may therefore be less susceptible to anti-inflammatory therapy.