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Comprehensive mismatch repair gene panel identifies variants in patients with Lynch-like syndrome.

Alexandre XavierMaren Fridtjofsen OlsenLiss A LavikJostein JohansenAshish Kumar SinghWenche SjursenRodney J ScottBente A Talseth-Palmer
Published in: Molecular genetics & genomic medicine (2019)
We have shown that other genes associated with the process of DNA MMR have a high probability of being associated with LLS families. These findings indicate that the spectrum of genes that should be tested when considering an entity like Lynch-like syndrome should be expanded so that a more inclusive definition of this entity can be developed.
Keyphrases
  • genome wide
  • copy number
  • case report
  • genome wide identification
  • dna methylation
  • circulating tumor
  • gene expression
  • bioinformatics analysis
  • nucleic acid