Comprehensive mismatch repair gene panel identifies variants in patients with Lynch-like syndrome.

Alexandre XavierMaren Fridtjofsen OlsenLiss A LavikJostein JohansenAshish Kumar SinghWenche SjursenRodney J ScottBente A Talseth-Palmer

Published in: Molecular genetics & genomic medicine (2019)

We have shown that other genes associated with the process of DNA MMR have a high probability of being associated with LLS families. These findings indicate that the spectrum of genes that should be tested when considering an entity like Lynch-like syndrome should be expanded so that a more inclusive definition of this entity can be developed.

Keyphrases

genome wide
copy number
case report
genome wide identification
dna methylation
circulating tumor
gene expression
bioinformatics analysis
nucleic acid