Cerebral autoregulation and neurovascular coupling are progressively impaired during septic shock: an experimental study.
Lorenzo FerliniFuhong SuJacques CreteurFabio Silvio TacconeNicolas GaspardPublished in: Intensive care medicine experimental (2020)
A progressive loss of dCA and NVC occurs during septic shock and is associated with cortical dysfunction. These findings indicate that the alteration of mechanisms controlling cortical perfusion plays a late role in the pathophysiology of SAE and suggest that alterations of CBF regulation mechanisms in less severe phases of sepsis reported in clinical studies might be due to patients' comorbidities or other confounders. Furthermore, a mean arterial pressure targeting therapy aiming to optimize dCA might not be sufficient to prevent neuronal dysfunction in sepsis since it would not improve NVC.
Keyphrases
- subarachnoid hemorrhage
- septic shock
- cerebral ischemia
- end stage renal disease
- ejection fraction
- oxidative stress
- newly diagnosed
- chronic kidney disease
- multiple sclerosis
- magnetic resonance imaging
- early onset
- magnetic resonance
- computed tomography
- patient reported outcomes
- acute kidney injury
- contrast enhanced
- patient reported
- cerebral blood flow
- drug induced
- smoking cessation