Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson's Disease.
Vibhor KrishnaPaul S FishmanHoward M EisenbergMichael KaplittGordon BaltuchJin Woo ChangWei-Chieh ChangRaul Martinez FernandezMarta Del AlamoCasey H HalpernPejman GhanouniRoberto EleopraRees CosgroveJorge GuridiRyder GwinnPravin KhemaniAndres M LozanoNathan McDannoldAlfonso FasanoMarius ConstantinescuIlana SchlesingerArif DalviW Jeff EliasPublished in: The New England journal of medicine (2023)
Unilateral pallidal ultrasound ablation resulted in a higher percentage of patients who had improved motor function or reduced dyskinesia than a sham procedure over a period of 3 months but was associated with adverse events. Longer and larger trials are required to determine the effect and safety of this technique in persons with Parkinson's disease. (Funded by Insightec; ClinicalTrials.gov number, NCT03319485.).