Disrupted Circadian Rhythm of Epinephrine in Males With Youth-Onset Type 2 Diabetes.
Stephanie GiessnerMegan E RamakerKathryn BlewMatthew L CrawfordRussell P GrantJames R BainMichael MuehlbauerNina JainDaniel S HsiaSarah ArmstrongMichael FreemarkPinar Gumus BalikciogluPublished in: Journal of the Endocrine Society (2022)
Circadian rhythm in catecholamines is disrupted in youth-onset T2D, with a blunted overnight fall in urinary epinephrine in males. Conversely, fasting morning norepinephrine and dopamine levels were lower in obese females with or without T2D. Higher nocturnal catecholamines in males with T2D might associate with, or predispose to, hypertension and cardiovascular complications. Lower catecholamine excretion in females with obesity might serve an adaptive, protective role.
Keyphrases
- type diabetes
- insulin resistance
- blood pressure
- weight loss
- metabolic syndrome
- mental health
- heart rate
- physical activity
- atrial fibrillation
- young adults
- adipose tissue
- glycemic control
- resting state
- blood glucose
- obstructive sleep apnea
- uric acid
- bariatric surgery
- weight gain
- functional connectivity
- sleep quality
- body mass index
- depressive symptoms
- arterial hypertension