Optimizing interpretation of survival studies of fresh and aged transfused biotin-labeled RBCs.
Albert D DonnenbergDaniel B Kim-ShapiroTamir KaniasLinda R MooreJoseph E KissJanet S LeeZeyu XiongLing WangDarrell J TriulziMark T GladwinPublished in: Transfusion (2022)
Similar clearance kinetics of fresh and aged BioRBC may be due to the extensive washing required during biotinylation. Survival kinetics consistent with cells with uniform rather than Gaussian or other non-uniform age distributions suggest that washing, and potentially RBC culling, may extend the storage life of RBC products.