The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval.
Kimberly R JordanMatthew J SikoraJill E SlanskyAngela MinicJennifer K RicherMarisa R MoroneyJunxiao HuRebecca J WolskyZachary L WatsonTomomi M YamamotoJames C CostelloAaron ClausetKian BehbakhtT Rajendra KumarBenjamin G BitlerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Multiomics profiling of ovarian tumor samples pre- and post-NACT provides unique insight into chemo-induced changes to the tumor microenvironment. We identified a novel IL6/IER3 signaling axis that may drive chemoresistance and disease recurrence.