Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol.

Claude F AlbrittonMert DemirciKit NeikirkLale A ErtugluJeanne A IshimweAshley L MutchlerQuanhu ShengCheryl L LafferCelestine N WanjallaTaseer AhmedAlexandria Porcia HaynesMohammad SaleemHeather K BeasleyAndrea G MarshallZer VueAlp T IkizlerThomas R KleymanValentina KonAntentor O HintonAnnet Kirabo

Published in: bioRxiv : the preprint server for biology (2024)

Our findings suggest that renal cortisol signaling via the GR but not the MR in APCs contributes to SSBP via cortisol. Urine and plasma cortisol may provide an important currently unavailable feasible diagnostic tool for SSBP. Moreover, cortisol-GR-SGK1-ENaC signaling pathway may provide treatment options for SSBP.

Keyphrases

signaling pathway
blood pressure
bone marrow
magnetic resonance
pi k akt
stem cells
epithelial mesenchymal transition
cell therapy
magnetic resonance imaging
computed tomography
immune response
oxidative stress
arterial hypertension