Clinicopathologic correlates and natural history of atypical chronic myeloid leukemia.
Guillermo Montalban BravoRashmi Kanagal-ShamanaKoiji SasakiLucia MasarovaKiran NaqviElias J JabbourCourtney D D DiNardoKoichi TakahashiMarina KonoplevaNaveen PemmarajuTapan Mahendra KadiaFarhad RavandiNaval G DaverGautam BorthakurZeev EstrovJoseph D KhourySanam LoghaviKelly A SoltysiakSherry PierceCarlos Bueso-RamosKeyur P PatelSrdan VerstovsekHagop M KantarjianPrithviraj BoseGuillermo Garcia ManeroPublished in: Cancer (2021)
aCML is characterized by high frequencies of ASXL1, SRSF2, and SETBP1 mutations and is associated with a high risk of acute myeloid leukemia transformation. Response and survival outcomes with current therapies remain poor. The incorporation of age, platelet counts, bone marrow blast percentages, and LDH levels can allow survival prediction, and allogeneic stem cell transplantation should be considered for all eligible patients.
Keyphrases
- stem cell transplantation
- bone marrow
- high dose
- acute myeloid leukemia
- chronic myeloid leukemia
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- mesenchymal stem cells
- prognostic factors
- low dose
- peritoneal dialysis
- allogeneic hematopoietic stem cell transplantation
- peripheral blood
- patient reported outcomes
- acute lymphoblastic leukemia