IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis.
Sungsin JoSung Eun WangYoung Lim LeeSuman KangBitnara LeeJinil HanIl-Hoon SungYe-Soo ParkSang-Cheol BaeTae Hwan KimPublished in: Arthritis research & therapy (2018)
Our findings indicate that IL-17A regulates osteoblast activity and differentiation via JAK2/STAT3 signaling. They shed light on AS pathogenesis and suggest new rational therapies for clinical AS ankylosis.