IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis.

Sungsin JoSung Eun WangYoung Lim LeeSuman KangBitnara LeeJinil HanIl-Hoon SungYe-Soo ParkSang-Cheol BaeTae Hwan Kim

Published in: Arthritis research & therapy (2018)

Our findings indicate that IL-17A regulates osteoblast activity and differentiation via JAK2/STAT3 signaling. They shed light on AS pathogenesis and suggest new rational therapies for clinical AS ankylosis.

Keyphrases

ankylosing spondylitis
disease activity
rheumatoid arthritis
signaling pathway
bone regeneration
systemic lupus erythematosus