Natural killer (NK) cells participate in cancer immunosurveillance and cancer immunotherapy. Live cell imaging of cancer cells targeted by NK cells, published today in BMC Biology by Zhu et al., reveals a remarkable diversity of programmed cell death pathways induced in individual cells. Pathway choice depends on the state of the target cell actin cytoskeleton and a novel death pathway, granzyme-induced necroptosis, could be of broad importance in cancer immunotherapy.
Keyphrases
- nk cells
- high glucose
- diabetic rats
- induced apoptosis
- high resolution
- single cell
- papillary thyroid
- drug induced
- cell cycle arrest
- systematic review
- cancer therapy
- mass spectrometry
- oxidative stress
- cell proliferation
- bone marrow
- signaling pathway
- fluorescence imaging
- meta analyses
- lymph node metastasis
- childhood cancer