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Micropapillary variant of mucinous carcinoma of the breast shows genetic alterations intermediate between those of mucinous carcinoma and micropapillary carcinoma.

Fresia ParejaPier SelenicaDavid N BrownAna P M SebastiaoEdaise M da SilvaArnaud Da Cruz PaulaAngela DelLi FuBritta WeigeltEdi BrogiJorge Sergio Reis-FilhoHannah Y Wen
Published in: Histopathology (2019)
MPMCs are heterogeneous at the genetic level; some tumours show a pattern of somatic genetic alterations similar to those of mucinous carcinomas, whereas others resemble invasive micropapillary carcinomas at the genetic level. These findings suggest that MPMCs may not constitute one histological subtype, but rather a convergent phenotype that can stem from mucinous carcinomas or invasive micropapillary carcinomas.
Keyphrases
  • low grade
  • high grade
  • genome wide
  • copy number
  • dna methylation
  • gene expression