Cervical cancer risk profiling: molecular biomarkers predicting the outcome of hrHPV infection.
Mariano A MolinaLudovica Carosi DiatricchMarina Castany QuintanaWillem Jg MelchersKarolina M AndralojcPublished in: Expert review of molecular diagnostics (2020)
Biomarkers such as p16/Ki-67, hrHPV genotyping, hrHPV transcriptional status, and methylation patterns have demonstrated promising results. Their eventual implementation in the screening programs may support the prompt diagnosis of hrHPV infection and its progression to cancer. These biomarkers will help in making clinical management decisions on time, thus, saving the lives of hrHPV-infected women, particularly in developing countries.
Keyphrases
- genome wide
- primary care
- healthcare
- public health
- gene expression
- high throughput
- polycystic ovary syndrome
- dna methylation
- transcription factor
- papillary thyroid
- single cell
- neoadjuvant chemotherapy
- quality improvement
- squamous cell carcinoma
- pregnant women
- radiation therapy
- young adults
- metabolic syndrome
- lymph node
- skeletal muscle
- pregnancy outcomes
- lymph node metastasis