Impact of Reduced Acidic Earwax pH and Earwax-Determinant Genotypes in Acquired Middle Ear Cholesteatoma.
Satoshi HaraTakeshi KusunokiHiroshi NakagawaKazusaku KamiyaYu ToyodaYusuke TakataTakashi AnzaiMasayuki FurukawaHiroko OkadaTakumi NakayamaKatsuhisa IkedaFumihiko MatsumotoPublished in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2024)
Our results show that the less acidic earwax pH was significantly related to the development and progression of acquired middle ear cholesteatoma. The less acidic earwax pH may play an important role in the mechanism underlying the association between acquired middle ear cholesteatoma and the ABCC11 gene at site 538.