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Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer.

Jeeshan JiffryThongthai ThavornwatanayongDevika RaoElisha J FogelDurvanand SaytooRishika NahataHillary GuzikImran ChaudharyTitto AugustineSanjay GoelRadhashree Maitra
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Pelareorep hijacks host autophagic machinery in KRAS-mut conditions to augment its propagation and preferential oncolysis of the cancer cells.
Keyphrases
  • wild type
  • cell death
  • endoplasmic reticulum stress
  • oxidative stress
  • signaling pathway