Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction.
Malka ShiloHadas OvedLior WertheimIdan GalNadav NoorOri GreenEster-Sapir BaruchDoron ShabatAssaf ShapiraTal DvirPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2021)
In a myocardial infarction, blood supply to the left ventricle is abrogated due to blockage of one of the coronary arteries, leading to ischemia, which further triggers the generation of reactive oxygen species (ROS). These sequential processes eventually lead to the death of contractile cells and affect the integrity of blood vessels, resulting in the formation of scar tissue. A new heart therapy comprised of cardiac implants encapsulated within an injectable extracellular matrix-gold nanoparticle composite hydrogel is reported. The particles on the collagenous fibers within the hydrogel promote fast transfer of electrical signal between cardiac cells, leading to the functional assembly of the cardiac implants. The composite hydrogel is shown to absorb reactive oxygen species in vitro and in vivo in mice ischemia reperfusion model. The reduction in ROS levels preserve cardiac tissue morphology and blood vessel integrity, reduce the scar size and the inflammatory response, and significantly prevent the deterioration of heart function.
Keyphrases
- reactive oxygen species
- left ventricular
- hyaluronic acid
- extracellular matrix
- induced apoptosis
- heart failure
- cell death
- inflammatory response
- cell cycle arrest
- drug delivery
- wound healing
- dna damage
- coronary artery
- soft tissue
- coronary artery disease
- skeletal muscle
- signaling pathway
- mesenchymal stem cells
- endoplasmic reticulum stress
- mass spectrometry
- pi k akt
- cell proliferation
- cell therapy
- lps induced