ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.

Rafael SchmidKatharina WolfJan W RoberingSelina StraußPamela L StrisselReiner StrickMatthias RübnerPeter A FaschingRaymund E HorchAndreas E KremerAnja M BoosAnnika Kengelbach-Weigand

Published in: BMC cancer (2018)

We here show that each mammary cell population plays a different role in the ATX-LPA axis with ADSCs and adipocytes being the main source of ATX in tumor patients in our experimental setting. Inhibitors of this axis may therefore present a valuable target for pharmacological therapies.

Keyphrases

end stage renal disease
adipose tissue
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
single cell
peritoneal dialysis
cell therapy
type diabetes
stem cells
mesenchymal stem cells
skeletal muscle
metabolic syndrome
patient reported outcomes
young adults