Regulatory Peptide Nesfatin-1 and its Relationship with Metabolic Syndrome.
Tuba TekinBetul CicekNurefşan Konyalıgil ÖztürkPublished in: The Eurasian journal of medicine (2019)
Metabolic syndrome is associated with a group of conditions abdominal obesity, high triglyceride levels, reduction in low-density lipoprotein, increased blood pressure, and increased fasting blood glucose. Hence, it poses a risk for type 2 diabetes and cardiovascular diseases. The prevalence of metabolic syndrome increases with age. Nesfatin-1, which affects different systems, has recently been discovered as a regulatory peptide molecule. With the discovery of nesfatin-1, it has been reported to inhibit the intake of nutrients and have significant regulatory effects on energy metabolism. As nesfatin-1 is present in both central and peripheral tissues, it is thought to have many functions. In addition to its suppressive effect on food intake, nesfatin-1 has also been reported to have an effect on the blood glucose level for regulating cardiac functions and affecting obesity by providing weight loss. Considering the effects of nesfatin-1, it may be associated with metabolic syndrome.
Keyphrases
- metabolic syndrome
- blood glucose
- glycemic control
- insulin resistance
- weight loss
- blood pressure
- type diabetes
- low density lipoprotein
- uric acid
- transcription factor
- cardiovascular risk factors
- cardiovascular disease
- bariatric surgery
- high fat diet induced
- small molecule
- weight gain
- left ventricular
- heavy metals
- heart failure
- hypertensive patients
- risk assessment
- roux en y gastric bypass
- body mass index
- physical activity
- cardiovascular events
- chemotherapy induced