Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats.

Roger HudsonChristopher NorrisHanna J SzkudlarekDinat KhanSusanne SchmidWalter J RushlowSteven R Laviolette

Published in: Psychopharmacology (2021)

These findings reveal critical new insights into the neuroanatomical and molecular mechanisms associated with the differential neuropsychiatric side effects of THC in dissociable nucleus accumbens sub-regions.

Keyphrases

signaling pathway
cell proliferation
pi k akt
single cell
sleep quality
gene expression
depressive symptoms
dna methylation
physical activity