Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats.
Roger HudsonChristopher NorrisHanna J SzkudlarekDinat KhanSusanne SchmidWalter J RushlowSteven R LaviolettePublished in: Psychopharmacology (2021)
These findings reveal critical new insights into the neuroanatomical and molecular mechanisms associated with the differential neuropsychiatric side effects of THC in dissociable nucleus accumbens sub-regions.