p52 signaling promotes cellular senescence.

Giovanna M BernalLongtao WuDavid J VoceRalph R WeichselbaumBakhtiar Yamini

Published in: Cell & bioscience (2022)

These results demonstrate that p52 nuclear translocation is increased in senescent cells by factors in conditioned media and that mature p52 induces cellular senescence. The data are consistent with the prior observation that p52 is elevated in aged tissue and support the hypothesis that p52 contributes to organismal aging.

Keyphrases

induced apoptosis
dna damage
endothelial cells
cell cycle arrest
stress induced
electronic health record
endoplasmic reticulum stress
oxidative stress
cell death
machine learning
deep learning