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Recording the wild lives of immune cells.

Mikaël J PittetChristopher S GarrisSean Philip ArlauckasRalph Weissleder
Published in: Science immunology (2019)
Intravital microscopic imaging can uncover fundamental aspects of immune cell behavior in real time in both healthy and pathological states. Here, we discuss approaches for single-cell imaging of adaptive and innate immune cells to explore how they migrate, communicate, and mediate regulatory or effector functions in various tissues throughout the body. We further review how intravital single-cell imaging can be used to study drug effects on immune cells.
Keyphrases
  • single cell
  • high resolution
  • rna seq
  • gene expression
  • high throughput
  • mass spectrometry
  • genetic diversity