Acid sphingomyelinase regulates TH 2 cytokine release and bronchial asthma.

Svenja BöllSebastian ZiemannKim OhlPatricia KlemmAnnette D RiegErich GulbinsKatrin Anne BeckerMarkus KamlerNorbert WagnerStefan UhligChristian MartinKlaus TenbrockEva Verjans

Published in: Allergy (2019)

Asm deficiency could induce higher numbers of TH 2 cells in the lung, but those cells release decreased TH 2 cytokine levels. Hereby, Asm-/- animals are protected from bronchial asthma, which possibly offers novel therapeutic strategies, for example, with ASM blockade.

Keyphrases

induced apoptosis
cell cycle arrest
chronic obstructive pulmonary disease
lung function
endoplasmic reticulum stress
allergic rhinitis
cell proliferation
pi k akt