Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease.
Robert A RissmanOliver LangfordRema RamanMichael C DonohueSara Abdel-LatifMatthew R MeyerTraci Wente-RothKristopher M KirmessJennifer NgolabCharisse N WinstonGustavo Jimenez-MaggioraMichael S RafiiPallavi SachdevTim WestKevin E YarasheskiJoel B BraunsteinMichael IrizarryKeith A JohnsonPaul S AisenReisa A Sperlingnull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
gov Identifier: NCT04468659 HIGHLIGHTS: The addition of plasma phosphorylated variant p-tau217 ratio (p-tau217/np-tau217) significantly improved plasma biomarker algorithms for identifying preclinical amyloid positron emission tomography positivity. Prediction performance at higher NAV Centiloid levels was improved with p-tau217/np-tau217. All models generated for this study are incorporated into the Plasma Predicted Centiloid (PPC) app for public use.