Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry.

Nils KappelmannMartin ReinJulia FietzHelen S MaybergW Edward CraigheadBoadie W DunlopCharles B NemeroffMartin KellerDaniel N KleinBruce A ArnowNusrat HusainRobin B JarrettJeffrey R VittenglMarco MenchettiGordon ParkerJacques P BarberAndre G BastosJack DekkerJaap PeenMartin E KeckJohannes Kopf-Beck

Published in: BMC medicine (2020)

This registered report showed no differences of ADM and psychotherapy for the treatment of MDD at sum-score and symptom levels. Symptom-based metrics such as the proposed SOrT metric do not inform allocation to these treatments, but predictive value of symptom information requires further testing for other treatment comparisons.

Keyphrases

patient reported
systematic review
healthcare
major depressive disorder
depressive symptoms
stem cells
emergency department
mesenchymal stem cells
bipolar disorder
health information
electronic health record
smoking cessation