SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL.

Changwei LiuLi NiXiaoxue LiHanyu RaoWenxin FengYiwen ZhuWei ZhangChunxiao MaYue XuLiming GuiZiyi WangRebiguli AjiJin XuWei-Qiang GaoLi Li

Published in: Clinical and translational medicine (2023)

Our findings reveal the role of SETD2-mediated H3K36me3 of Smad7 in regulating the TGF-β/Smad signalling pathway in renal fibrogenesis and provide an innovative insight into SETD2 as a potential therapeutic target for the treatment of renal fibrosis.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
gene expression
single cell
genome wide
dna methylation
signaling pathway
risk assessment
liver fibrosis