Plasma leptin is associated with amyloid CSF biomarkers and Alzheimer's disease diagnosis in cognitively impaired patients.
Matthieu LilamandElodie Bouaziz-AmarJulien DumurgierEmmanuel CognatClaire HourregueFrançois Mouton-LigerManuel SanchezAnne-Cécile TroussièreMatthieu MartinetJacques HugonClaire PaquetPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)
Plasma leptin levels were associated with CSF Aβ and with the diagnosis of AD confirmed by CSF biomarkers, suggesting a molecular interplay between leptin metabolism and brain amyloid deposition.