Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma.
Michelle J LeeJean L KoffJeffrey M SwitchenkoC Ileen JhaneyR Andrew HarkinsSharvil P PatelSandeep S DaveChristopher R FlowersPublished in: Cancer (2020)
Distinct prevalence and patterns of mutation highlight an important difference in the mutational landscapes of DLBCL arising in different ancestry groups. To the authors' knowledge, the results of the current study provide the first-ever characterization of genetic alterations among patients with African descent who are diagnosed with DLBCL.