Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular Dysfunction.

Kristen D OnosPeter B LinRavi S PandyScott A PersohnCharles P BurtonEthan W MinerKierra EldridgeJonathan Nyandu KanyindaKate E FoleyGregory W Carter Gareth R Howell Paul R Territo

Published in: bioRxiv : the preprint server for biology (2024)

This work highlights APOEe4 status in AD progression manifest as neurovascular uncoupling driven by immunological activation, and may serve as an early diagnostic biomarker.

Keyphrases

nitric oxide synthase
cognitive decline
high fat diet
type diabetes
nitric oxide
adipose tissue
skeletal muscle