Topotecan clearance based on a single sample and a population pharmacokinetic model: Application to a pediatric high-risk neuroblastoma clinical trial.
Olivia CampagneHuiyun WuJianrong WuArlene NaranjoVinay M DaryaniAmar J GajjarJulie R ParkClinton F StewartPublished in: Pediatric blood & cancer (2023)
A simple single-sample approach during topotecan therapy could guide dosing for patients, resulting in more patients reaching target attainment.