NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis.

Elena ShersherMohini LahiryAnnamil Alvarez-TrottaGiulia DiluvioDavid J RobbinsRamin ShiekhattarAnthony J Capobianco

Published in: Cell communication and signaling : CCS (2021)

This study identifies the INT complex as a novel co-factor in Notch-mediated transcription that together with NACK activates Notch target genes and leads to cancer cell proliferation. Video abstract.

Keyphrases

cell proliferation
genome wide
transcription factor
cell cycle
papillary thyroid
pi k akt
squamous cell
dna methylation
gene expression