Extreme elevations of donor-derived cell-free DNA increases the risk of chronic lung allograft dysfunction and death, even without clinical manifestations of disease.

Michael B KellerDavid NewmanMuhtadi AlnababtehLucia PonorPali ShahJoby MathewHyesik KongTemesgen AndargieWoojin ParkAnanth CharyaHelen LuikartShambhu AryalSteven D NathanJonathan B OrensKiran K KhushMoon JangSean Agbor-Enoh

Published in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2024)

Episodes of EMI in lung transplant recipients are often isolated and may not be detectable with traditional clinical monitoring approaches. EMI is associated with an increased risk of severe CLAD or death, independent of concomitant transplant complications.

Keyphrases

oxidative stress
climate change
risk factors
early onset