Cortical spreading depression as a site of origin for migraine: Role of CGRP.

Liesl N CloseSajedeh EftekhariMinyan WangAndrew C CharlesAndrew F Russo

Published in: Cephalalgia : an international journal of headache (2018)

This review will outline calcitonin gene-related peptide-cortical spreading depression connections and propose a model in which cortical spreading depression and calcitonin gene-related peptide act at the intersection of the vasculature and cortical neurons, and thus contribute to migraine pathophysiology.

Keyphrases

depressive symptoms
sleep quality
copy number
genome wide
spinal cord
gene expression
spinal cord injury
drug induced