Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review.

Willem W B de KortS SpelierL A DevrieseR J J van EsS M Willems

Published in: Molecular diagnosis & therapy (2021)

Several EGFR-PI3K-AKT-mTOR-pathway inhibitor biomarkers have been researched for HNSCC but few of the investigated biomarkers have been adequately confirmed in clinical trials. A more systematic approach is needed to discover proper biomarkers as stratifying patients is essential to prevent unnecessary costs and side effects.

Keyphrases

small cell lung cancer
clinical trial
end stage renal disease
epidermal growth factor receptor
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
mass spectrometry
high resolution