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cAMP-dependent regulation of RhoA/Rho-kinase attenuates detrusor overactivity in a novel mouse experimental model.

William AkakpoBiljana MusickiArthur L Burnett
Published in: BJU international (2017)
Impaired denitrosylation is associated with detrusor overactivity, which is linked with upregulated RhoA/Rho-kinase signalling. Colforsin reverses physiological and molecular abnormalities. This study describes a novel model of detrusor overactivity and suggests a possible basis for its treatment.
Keyphrases
  • botulinum toxin
  • protein kinase
  • tyrosine kinase
  • single molecule
  • combination therapy
  • replacement therapy