Development and validation of an ultrafast method of quantification of rivaroxaban in human serum using laser diode thermal desorption coupled to triple quadrupole mass spectrometry.
Mégane MoreauSerge AugerPierre PicardJean LacoursièrePedro A SeguraPublished in: Rapid communications in mass spectrometry : RCM (2024)
This method improves sample throughput by more than 1200% compared to liquid chromatography-tandem mass spectrometry methods of analysis of rivaroxaban and decreases analysis costs by reducing solvent consumption and instrument time.
Keyphrases
- liquid chromatography tandem mass spectrometry
- mass spectrometry
- simultaneous determination
- liquid chromatography
- high performance liquid chromatography
- venous thromboembolism
- solid phase extraction
- atrial fibrillation
- tandem mass spectrometry
- pulmonary embolism
- gas chromatography
- ms ms
- high resolution
- patient reported outcomes
- energy transfer