The Pharmacobiochemical Effects of Ethanol Extract of Justicia secunda Vahl Leaves in Rattus Norvegicus.
Anthony U OnochieAdaobi Helen OliAngus Nnamdi OliObiajulu Christian EzeigweAndrew C NwakaChukwudi O OkaniPrinceston Chukwuemeka OkamChibueze P IhekweremeJude Nnaemeka OkoyehPublished in: Journal of experimental pharmacology (2020)
The ethanol leaf extract of Justicia secunda has negative cardiac and renal effects on Wistar rats, causing increased lipid profile values, creatinine and blood urea levels in the experimental animals compared with control. The LD50 is below the safety level. Caution should be exercised as the biochemical profiles of cardiac and renal effects do not seem to be promising and the LD50 is below the safety level.