Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS.
Haoyue ZhouFeng GaoXiaoli YangTingting LinZhenxing LiQiong WangYang YaoLei LiXinxin DingKaibin ShiQiang LiuHong BaoZhenyu LongZujun WuRobert VassarXin ChengRena LiYong ShenPublished in: Circulation research (2022)
Our findings establish a novel and direct relationship between endothelial BACE1 and cerebral small vessel damage, indicating that abnormal elevation of endothelial BACE1 is a new mechanism for cerebral small vessel disease pathogenesis.