The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid-induced impaired wound healing.

Van Tuan Nguyen Qui Trung Ngo Roberto Palacios Ramirez Toshifumi Nakamura Nicolette Farman Selim Aractingi Frédéric Jaisser

Published in: British journal of pharmacology (2022)

Topical MR antagonism facilitates the switching of macrophages towards an anti-inflammatory phenotype, which improves prolonged inflammation and induces angiogenesis to accelerate wound healing delayed by glucocorticoid treatment.

Keyphrases

wound healing
oxidative stress
anti inflammatory
diabetic rats
high glucose
bone marrow
magnetic resonance
dendritic cells
acute myeloid leukemia
endothelial cells
magnetic resonance imaging
contrast enhanced
immune response
vascular endothelial growth factor
replacement therapy